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Pharmaceutical EDI for manufacturer and specialty-supplier mandates

ANSI X12 order-to-cash and product-activity flows between manufacturers, specialty suppliers, and pharmaceutical wholesalers (McKesson, Cardinal Health, Cencora). Identity often uses NDC/GTIN/GLN alongside ISA/GS envelopes. Transport is typically AS2 or SFTP per partner guide.
pharmaceutical EDIwholesaler X12NDCAS2

What to know

ANSI X12 order-to-cash and product-activity flows between manufacturers, specialty suppliers, and pharmaceutical wholesalers (McKesson, Cardinal Health, Cencora). Identity often uses NDC/GTIN/GLN alongside ISA/GS envelopes. Transport is typically AS2 or SFTP per partner guide.

  • Common sets: 850, 855, 856, 810, 832, 852, 844, 849, 997.
  • Not the same as payer claims EDI (837/835/270/271). Route claims buyers to /healthcare-edi.
  • Identity often combines ISA/GS envelopes with NDC, GTIN, and GLN location codes.
  • Transport is usually AS2 or SFTP — confirm the active McKesson, Cardinal, or Cencora guide.
  • Open to both brand manufacturers selling into the Big 3 and specialty pharmacies / smaller distributors.

Readiness language only — confirm every McKesson, Cardinal Health, and Cencora requirement in the partner implementation guide. SignalEDI does not issue DSCSA or FDA certifications.

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